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Objective:To review the experience of cardiopulmonary bypass in infants weighting less than 5kg from Jan.2007 to May 2007.Methods:27 infants with age 2.76 ± 1.55m and weight 4.37 ± 0.63kg.The apparatus of bypass included:Stockert Ⅲ and Terumo System I heart-lung machine,Dideco DATA Master continuous SpO2 detector,Terumo baby RX and Dideco 901 membrane oxygenator,Dideco hemoconcentrator.