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目的 To examine associations between serum lipids and age related macular degeneration(AMD).方法 A systematic search of the PubMed,EMBASE and ISI web of science databases was used to identify eligible published literatures without language restrictions up to January,2015.Summary relative ratios(RRs)and 95％CIs were estimated using fixed-effects model or random-effects model.结果 After ineligible studies were excluded,23 articles(21 studies)including 198,115 participants,were identified in this meta-analysis.The pooled relative ratio of HDL-C was 1.19(95％confidence interval 1.04 to 1.35)for an increment of per 1 mmol/l,with significant heterogeneity(I2=63.2％,P＜0.001).This factor was also significantly associated with an increased risk of early AMD(RR,1.16； 95％CI,1.01 to 1.31； I2=54.4％； P=0.008).An inverse association was observed between TC,LDL and TG levels with early and any AMD(early AMD：OR ranging from 0.91 to 0.95； any AMD：OR ranging from 0.91 to 0.94； all P＜0.05).结论 AMD was related to high HDL concentration,whereas the elderly patients with high TC,LDL and TG concentrations may be at decreased risk for this disease.