【摘 要】
：
Cytotoxic agents generally display little or no specificity,although cancer chemotherapy requires the preferential killing of rapidly proliferating tumor ce
【机 构】
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InstituteofEnzymology,BiologicalResearchCenterHungarianAcademyofSciencesHungary
【出 处】
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2008中国深圳蛋白质和多肽科学大会
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Cytotoxic agents generally display little or no specificity,although cancer chemotherapy requires the preferential killing of rapidly proliferating tumor cells.The lack of specificity leads to systemic toxicity causing undesirable side effects.Microtubule systems as the major constituent of the mitotic spindle,represent one of the best cancer targets identified so far,and a large group of bis-indole derivatives has been recognized for a long time as potent anti-tumor agents.Bisindols effectively arrest cell division; however,their use is limited in clinical chemotherapy because of undesirable side-effects.We identified mechanisms which could be responsible for these unwanted effects,and developed a potential anticancer agent,a semi synthetic vinblastine derivative with unique pharmacology.<省略>=We
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