【摘 要】
：
Several naturally occurring peptides and depsipeptides which include the cryptophycins,dolastatin 10,hemiasterlin,and phomopsin A have been found to be pote
【机 构】
：
TheCenterforComputationalBiologyWashingtonUniversityinSt.LouisUSA
【出 处】
：
2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
Several naturally occurring peptides and depsipeptides which include the cryptophycins,dolastatin 10,hemiasterlin,and phomopsin A have been found to be potent antimitotic agents,causing cell death at picomolar or low nanomolar concentrations.These compounds inhibit microtubule growth,modulate the dynamics of microtubules,and induce the self-association of tubulin dimers into single-walled rings and spirals.These peptides also exhibit mutual competitive inhibition in binding to beta-tubulin,while noncompetitively inhibiting the binding of vinblastine and vincristine to beta-tubulin.
其他文献
Peptidomic studies,i.e.total screening of biological samples for peptides hold considerable promise for elucidating biochemical regulatory networks and for
Parkinsons disease (PD) is the second most common neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the substantia ni
IGF-1 and its binding proteins and receptors are induced within damaged brain regions following ischemia and exogenous administration of IGF-1 after injury
Normally,investigation of a protein-protein interaction is limited to studying how one single molecule interacts with another.However,new evidence shows tha
Transdifferentiation and stem cell fusion with host cells are thought to be the two primary mechanisms of stem cell protection against neuronal injury after
Astrocytes and microglia are two different types of glial cells,both of which are attracting wide interest in thepain field on account of their roles in the
Haptoglobin (Hp) is known as an acute phase protein in response to infection and inflammation.Two common alleles,Hp 1 and Hp 2,determine each individual wit
Hypertension is a major risk factor in cardiovascular disease,a leading cause of death in Canada and many countries worldwide.Angiotensin-Ⅰ-converting enzy
In contrast to the notion established for many years that protein function depends on rigid 3D structures,nowadays there is importantevidence suggesting tha
Tumor development has long been known to resemble abnormal embryogenesis.The embryonic stem cell (ESC) self-renewal genes Nanog and Oct4 are purportedly exp