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  5. Molecular Studies on Binding Interaction Between β2-GPI and Oxidized LDL and β2-GPI-specific Ligands

Molecular Studies on Binding Interaction Between β2-GPI and Oxidized LDL and β2-GPI-specific Ligands

来源 :2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会) | 被引量 : 0次 | 上传用户：svkisahero
【摘 要】
：
β2-glycoprotein I(β2-GPI) is a major antigen for anticardiolipin antibodies(aCL,Abs) present in patients with antiphospholipid syndrome.The domain V of β2-GPI has a potent phospholipids binding region
【作 者】
：
Qingping Liu Amei Chen Zhe Liu Renjun Wang 
【机 构】
：
Departpent of Biochemistry and Molecular Biology,Bioengineering College, Dalian University, Dalian 1
【出 处】
：
2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会)
【发表日期】
：
2005年12期
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　　β2-glycoprotein I(β2-GPI) is a major antigen for anticardiolipin antibodies(aCL,Abs) present in patients with antiphospholipid syndrome.The domain V of β2-GPI has a potent phospholipids binding region.A structure consisting of a particular region,K282NKEKK287,was identified to be involved in binding to phospholipids,using synthesized peptides and mutant proteins of β2-GPI.β2-GPI affects multiple phospholipids-dependent coagulation pathways but also lipoprotein metabolism.
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