论文部分内容阅读
OBJECTIVE To examine whether PEBP partici pates in opioid dependence through modulating activation of MAPK pathway.METHODS AND RESULTS In CHO cell stably expressing μ receptor (MOR-CHO) or SH-SY5Y cell expressing endogenous μ receptor, morphine stimulated phos phorylation of ERK but not PEBP in time-and dose-dependent manner.No significant change of pPEBP or PEBP was detected after a 48h chronic treatment of morphine in MOR-CHO or SH-SY5Y cell.