Recruitment of Transient Receptor Potential Canonical 1 Channel to lipid raft is required for fMLP-i

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Neutrophils are the first line of host defense against invading microorganism or other inflammatory stimuli in the innate immune system, and contribute to inflammation-related tissue injuries, associated with several human diseases including asthma, rheumatoid arthritis, tendonitis, bursitis, atherosclerosis, etc.
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A renewable source of human nociceptive sensory neurones is needed to enable new target identification and validation as well as allowing native human pharmacology to be generated in support of drug d
Ca2+-activated Cl-channels (CaCCs) are an important group of ion channels with diverse physiological roles including epithelial transport, smooth muscle contraction,neuronal excitability and sensory t
Among all sensory organs in mammals, those that sense light touch are the least understood mechanistically.Friedrich Merkel proposed 138 years ago that Merkel cells are mammalian tactile-transducers b
Retinoids are structurally related derivatives of vitamin A and are required for normal vision as well as cell proliferation and differentiation.Clinically, retinoids are effective in treating many sk
Purinergic signaling contributes significantly to cutaneous, musculoskeletal and visceral nociception and on the roles played by P2X3, P2X2/3, P2X4, P2X7 ATP receptor channels in neuropathic and infla
M-type K+ channels, encoded by the KCNQ2-5 family of genes, play key roles in the regulation of neuronal excitability.We study the regulation of M-channel activity and transcriptional expression by A-
Transient receptor potential (TRP) channels are polymodal cation channels that provide one of the main pathways for cation influx in excitable and non-excitable cells.Among them, the six thermo-sensit
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TRP
Phosphoinositides are a family of phospholipids in the cytoplasmic leaflet of plasma membranes and cell organelles.They are minority lipids differing by the degree of phosphorylation of the inositol h