【摘 要】
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Background, Motivation and Objective Ultrasound (US) mediated drug delivery is a field with promising results although the exact mechanisms behind intracellular delivery of drugs remain to be elucidat
【机 构】
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INSERM UMR 1032, France INSERM UMR 1033, France
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Background, Motivation and Objective Ultrasound (US) mediated drug delivery is a field with promising results although the exact mechanisms behind intracellular delivery of drugs remain to be elucidated. Most of the studies used drug carriers and cavitation to enhance drug uptake in tumor cells. However, cavitation could induce cell lysis and remain difficult to control and predict in vivo. In this study, low intensity ultrasound with proper sonication parameters were used to induce clathrin-mediated endocytosis and to force the penetration of a bisphosphonate (Zoledronic acid: ZOL) into tumor cells.
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