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Discovery of novel olean-28,13β-lactams as potent anti-tumor agents
【出 处】
：
全国药物化学学术会议暨第四届中英药物化学学术会议
【发表日期】
：
2013年11期
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The roles of R2-carboxylate substitutent in determining binding affinity and interaction mode of tri
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Camptothecin(CPT)is a pentacyclic alkaloid that was isolated by Wall and Wani from Camptotheca acuminate in 1966,and show potent inhibitory activity against a broad spectrum of tumors.
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会议
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微生物次级代谢产物是药物先导化合物的重要来源，而且以放线菌为主。近年来，从陆生放线菌分离新活性化合物的速度大幅度降低，且重复率高，科研人员逐渐将研究重点由陆生转向一些特殊环境，如植物内生、高温、盐碱环境和海洋等。
非喜树碱类拓扑异构酶Ⅰ(Top1)抑制剂有望从根本上克服现有喜树碱类抗癌药易水解、易从切割复合物解离、水溶性差、易耐药等问题，已成为抗癌药研究领域热点。
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