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  5. ETFβ, a Novel Mediator of Free Fatty Acids Oxidation, Attenuates the Progression of Diabetic Nephrop

ETFβ, a Novel Mediator of Free Fatty Acids Oxidation, Attenuates the Progression of Diabetic Nephrop

来源 :2014年第十二届全国脂质与脂蛋白学术会议 | 被引量 : 0次 | 上传用户：huanyu2121
【摘 要】
：
Background and purpose: Elevated extracellular free fatty acids (FFAs) can induce tubular epithelial cell apoptosis, thereby contributing to the pathogenesis of diabetic nephropathy(DN).The progressio
【作 者】
：
Hua Wang Tingting Zhao Sifan Sun Ping Li 
【机 构】
：
Chinese Academy of Medical Science & Peking Union Medical College;Department of Pharmacology,Institu
【出 处】
：
2014年第十二届全国脂质与脂蛋白学术会议
【发表日期】
：
2014年7期
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Background and purpose: Elevated extracellular free fatty acids (FFAs) can induce tubular epithelial cell apoptosis, thereby contributing to the pathogenesis of diabetic nephropathy(DN).The progression of DN correlates best with tubular epithelial apoptosis and interstitial fibrosis.However, molecular mechanisms of FFA-induced tubular epithelial cell apoptosis are not clear.Electrontransfer flavoprotein (ETF) accepts electrons from the oxidation of fattyacids.Point mutations of ETFβ have been found in the renal cortex of spontaneous Otsuka Long Evans Tokushima Fatty (OLETF) diabetic rats.
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