Novel Bifunctional Alkylating Agents,Benzo [d]pyrrolo [2,1-b]thiazole Derivatives,Synthesis and Anti

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：luck_mike

【摘要】

：

【作者】

：

Satishkumar Tala Ravi Chaniyara Chi-Wei Chen Wilson Christian Krunal Mehariya Ting-Chao Chou Te-Chang Lee Tsann-Long Sua

【机构】

：

Institute of Biomedical Sciences,Academia Sinica,Taipei 11529

【出处】

：

第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

：

2012年8期

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　　A series of novel 2,3-bis(hydroxymethyl)benzo[d]pyrrolo[2,1-b]-thiazoles and their bis(alkylcarbamate) derivatives were synthesized for antitumor evaluation.The preliminary antitumor studies reveal that bis(hydroxymethyl) and their bis(alkylcarbamate) derivatives show significant antitumor activity in inhibiting human leukemia and various solid tumor cell growth in vitro.

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