Enantioselective hydrolysis of racemic epoxides mediated by epoxide hydrolases (EHs) is one of the most promising approaches to obtain enantiopure epoxides.In this study, we identified and characteriz
Curvulamine is a novel alkaloid with strong antimicrobial activity produced by the marine-derived fungus Curvularia sp.IFB-Z10.In this work, the effect of different carbon and nitrogen source on the c
果胶和木聚糖是存在于自然界中非常丰富的可再生资源，但有时这些资源并没有得到很好地发掘和利用，反而造成了环境污染。有效地转化和利用这类丰富的可再生资源需要多种酶的共同参与，其中α-L-阿拉伯呋喃糖苷酶起着非常重要的作用，是本课题的研究重点。它减少阿拉伯糖侧枝产生的空间位阻，使得内切型酶更易结合和分解聚糖主链，从而大大增加水解效率。本研究主要包括以下四个部分。
Reversible lysinc acetylation (RLA) is used by cells of all domains of life to modulate protein function.To date, bacterial acetylation/deacetylation systems have been studied in a few bacteria (e.g.,
From an environmental perspective, utilizing nonconventional solvents (i.e.green solvents) with low ecological footprint is a highly beneficial alternative to the conventional organic solvents to form
Symbiotic fungi have been witnessed to be a rich source of novel natural products with unforeseeable architectures and excellent biological activities.Recent attempts for drug discovery emphasize that
Due to plants of the Dipterocarpaceae family living in the tropical regions with strong UV light, and plant diseases and insect pests, the long-term evolution makes them produce resveratrol oligomers
微生物来源的天然产物在现代药物研发过程中起着关键作用,尤其是在肿瘤,感染,脂代谢失调以及免疫缺陷疾病的治疗过程中,次生代谢产物一直被证明是新型治疗药物以及先导化合物的持久而有效的来源(J.Nat.Prod.2012,75,311).随着基因组测序技术的飞速发展,多种微生物的全基因组信息已经被阐明,但研究发现,在正常实验室培养条件下,微生物体内大部分次生代谢基因处于"沉默"状态,即低表达或者不表达,
Objective: The goal of the present study was to improve the production of HMG-CoA reductase inhibitors, through optimize the fermentation medium and conditions of marine microorganism Fusarium solani
萜类化合物是自然界中广泛存在的一类天然烃类化合物,普遍存在于高等植物、真菌、微生物、昆虫、以及海洋生物中,具有异戊二烯单元组成的基本骨架,通式为(C5H8)n,其主要的生理药理活性包括昆虫拒食性,生长调节作用,抗氧化活性,抗真菌和微生物活性,以及细胞毒性、抗癌(他克唑和紫苏醇)、抗疟(青蒿素)、抗溃疡、抗肝炎、抗菌和利尿(甘草素)等功效,是中药和天然植物药的主要有效成分。同时萜类化合物也是一类重要