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  5. Delivery of therapeutics using nanolipoprotein particles for targeting glioblastoma cells and gliobl

Delivery of therapeutics using nanolipoprotein particles for targeting glioblastoma cells and gliobl

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：norn1
【摘 要】
：
Glioblastoma(GBM) is a highly aggressive brain tumor, with dismal survival outcomes.Glioblastoma stem cells (GSCs) have been demonstrated to play a role in therapeutic resistance and are considered to
【作 者】
：
Yuan Yu Wenqian Geng Ying Lu Yanqiang Zhong 
【机 构】
：
Department of Pharmaceutics, School of Pharmacy, The Second Military Medical University, Shanghai,Ch
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
【发表日期】
：
2015年9期
【关键词】
：
Glioblastoma Low density lipoprotein Angiopep-2 peptide 
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　　Glioblastoma(GBM) is a highly aggressive brain tumor, with dismal survival outcomes.Glioblastoma stem cells (GSCs) have been demonstrated to play a role in therapeutic resistance and are considered to be the most likely cause of cancer relapse.Low-density lipoproteins (LDL) has high-payload capacity and is biocompatible and nonimmunogenic, in the meanwhile potential use of LDL as nanocarriers for targeted delivery of cancer therapeutics has been recognized because numerous tumors overexpress LDL receptors (LDLR).
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