【摘 要】
：
Dicamba (3,6-dichloro-2-methoxybenzoicacid) is a benzoic acid herbicide and widely used in agriculture, which has been detected in surface-water and groundwater.In this study, to determine the endocri
【机 构】
：
Beijing Fishery Research Institute, Beijing 100068, China;State Key Laboratory of Environmental Aqua
【出 处】
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2016(第二届)毒性测试替代方法与转化毒理学(国际)学术研讨会暨有害结局路径(AOP)与风险评估培训会议
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Dicamba (3,6-dichloro-2-methoxybenzoicacid) is a benzoic acid herbicide and widely used in agriculture, which has been detected in surface-water and groundwater.In this study, to determine the endocrine disruption effects of dicamba, adult fish were separately exposed to concentrations 0, 0.05, 0.5, 5 and 50 μg/L for 40 days.The results showed that the transcription of thyroid hormones (THs) related genes including thyroid hormone receptor α (trα), transthyretin (ttr), thyroid peroxidase (tpo), deiodinase (dl, d2 ,d3) from adult livers were evaluated After 40 d exposure, the mRNA expressions of d3 were significantly down-regulated in the livers of male and female (p<0.01), whereas ttr and dl were significantly up-regulated (p<0.01).Meanwhile,significantly up-regulation of trα, tpo and d2 were observed in the livers of females (p<0.01) but significantly down-regulated in males (p<0.05).These results indicate that dicamba had negative effects on thyroid system in males and females.Therefore, dicamba could be a potential endocrine disruptor.
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