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Objective To observe the effects of manganismus on neurobehavior and neurogenesis,and analyze their correlation.Materials and methods; 28 two-weeks-old mice were divided into 4 groups:control group(CG),low-dose group (LDG),middling-dose group(MDG)and high-dose group(HDG).They respectively received intraperitoneal injection of 0,5,20,50mg/kg.d manganese chloride dissolved in physiological saline.The ability of learning and memory was tested by Morris Water Maze(MWM).The proliferation of NSCs in mouse SGZ and SVZ was detected by immuno-histochemistry.