Highly Enantioselective Michael Addition of 2-Oxindoles-3-Carboxylate Ester to Nitroolefins Promoted

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户:vsrabbithhf
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  Oxindole alkaloids bearing a quaternary carbon stereocenter,especially spirooxindoles,represent a prevalent scaffold found in natural products and biologically active compounds.Ethyl 2-oxindoles-3-carboxylate which could directly install the valuable malonate ester moiety,were employed as a nucleophile to give spirooxindole via asymmetric Michael addition to nitroolefins using organocatalyst.
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