Using a QSPR Approach to Develop Better Thiobenzanilide Scaffolds to Fight Tuberculosis

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：ASky2009

【摘要】

：

Tuberculosis,an infectious disease caused by Mycobacterium tuberculosis(M.tb),affects currently one third of the worlds population(data from WHO)1 and has become a serious threat to global health due

【作者】

：

Susana Borges Susans Santos Filomena Martins Assmah Sheik Ricardo Assun(c)(a)o In(e)s Pereira Marina Reis Soraia Martins Daniel Bandarra Margarida Meireles Cristina Ventura

【机构】

：

Cento de Química e Bioquímica(CQB),Departamento de Química e Bioquímica,FCUL,Ed.C8,Campo Grande 1749

【出处】

：

第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

：

2012年8期

【关键词】

：

thiobenzanilides QSPR logP cytotoxicity

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　　Tuberculosis,an infectious disease caused by Mycobacterium tuberculosis(M.tb),affects currently one third of the worlds population(data from WHO)1 and has become a serious threat to global health due to the emergence and spread of multidrug and extensively drug-resistant strains.Finding drugs to treat resistant strains of M.tb is therefore a major goal of medicinal chemistry.

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Using a QSPR Approach to Develop Better Thiobenzanilide Scaffolds to Fight Tuberculosis

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