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Objectives To study troglitazonE-induced liver mitochondrial toxicity in HepaRG cells and explore its possible mechanism to guide the identification and prevention mitochondrial toxicity for these drugs.Methods Human hepatocytes HepaRG cell line were incubated with troglitazone 12.5μ M 、 25μ M or 50μ M for 48h.The Seahorse Biosciences XF24 Flux Analyzer was used to measure mitochondrial oxygen consumption simultaneously.