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DNA非整倍体是恶性肿瘤的特征性标志之一。测量和分析细胞核DNA含量与倍体对恶性肿瘤的病理诊断、恶性程度判定、疗效估价、预测预后具有重要价值。其主要测定方法有流式细胞术和细胞图像光度术。本文主要综述了肿瘤细胞DNA干系倍体分析及其临床应用的现状以及流式细胞术和细胞图像光度术两种检测方法的优缺点和相应的改进方法,希望对其应用于临床以提高诊断的准确性和预测肿瘤的发展起到积极的作用。
DNA aneuploidy is one of the hallmarks of malignant tumors. Measurement and analysis of nuclear DNA content and ploidy on the pathological diagnosis of malignant tumors, to determine the degree of malignancy, efficacy evaluation, prediction of prognosis of great value. The main measurement methods are flow cytometry and cell imaging photometry. This review summarizes the advantages and disadvantages of the two methods of flow cytometry and cell image photometry in the analysis of DNA polyploidy of tumor cells and their clinical application and their corresponding improvement methods. It is hoped that this method can be used clinically to improve diagnosis Accuracy and predict the development of the tumor play a positive role.