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Objective: A meta-analysis was recently conducted in East-Asian advanced non-squamous non-small cell lung cancer (nsq-NSCLC) patients based on available individual patient data from three randomized phase Ⅲ trials (JMDB, S380 and JMIL).Particularly, it is our interest here to look at the efficacy and safety of pemetrexed plus platinum and other platinum based doublet regimens in elderly East-Asian patients.