论文部分内容阅读
目的比较不同分期的皮肤T细胞淋巴瘤(cutaneous T cell lymphom a,CTCL)患者外周血淋巴细胞表面抗原CD7的缺失情况。方法回顾性分析2006年1月-2010年7月本科收治的41例CTCL患者及9例炎症性皮肤病患者外周血淋巴细胞免疫表型的流式细胞检测结果,分析外周血CD7表达。结果 41例CTCL患者中,早期(IA~ⅡA)23例和进展期(ⅡB~ⅣB)18例,CD3+CD7-T细胞比例进展期组与炎症性皮肤病组及早期组比较,均明显升高(P<0.05)。进展期18例患者中6例CD7缺失(33.33%),早期23例患者中仅1例CD7缺失(4.35%),提示CD7缺失在进展期显著高于早期(P<0.05)。无外周血累及的25例蕈样肉芽肿(mycosis fungoides,MF)患者中有2例CD7缺失,均为进展期,提示进展期MF较早期MF更易出现CD7缺失(P<0.05);在进展期MF的CD3+CD7-T细胞比例均高于早期MF和炎症性皮肤病组(P<0.05)。结论 进展期CTCL和无外周血累及的进展期MF外周血CD3+CD7-T细胞比例明显高于早期及炎症性皮肤病组,CTCL进展期较早期更容易发生外周血CD7缺失。
Objective To compare the deletion of peripheral blood lymphocyte surface antigen CD7 in patients with cutaneous T cell lymphoma (CTCL) at different stages. Methods The results of flow cytometry analysis of peripheral blood lymphocyte immunophenotypes in 41 CTCL patients and 9 inflammatory skin disease patients from January 2006 to July 2010 were analyzed retrospectively. CD7 expression in peripheral blood was analyzed. Results Among the 41 patients with CTCL, 23 cases of early stage (IA ~ ⅡA) and 18 cases of advanced stage (ⅡB ~ ⅣB), the ratio of CD3 + CD7-T cells in progressive stage group was significantly higher than that in inflammatory stage group and early stage group High (P <0.05). Of the 18 patients with advanced disease, 6 had CD7 deletion (33.33%), only 1 of 23 patients had CD7 deletion (4.35%) in the early stage, suggesting that CD7 deletion was significantly higher in the advanced stage than in the early stage (P <0.05). There were 2 cases of CD7 deletion in 25 cases of mycosis fungoides (MF) without progression of peripheral blood, all of which showed that the progress of MF was more prone to CD7 deletion than that of early MF (P <0.05) MF of CD3 + CD7-T cells were higher than the early MF and inflammatory skin disease group (P <0.05). Conclusions The proportion of CD3 + CD7-T cells in advanced peripheral blood with advanced CTCL and without peripheral blood is significantly higher than that in early stage and inflammatory dermatosis group. The early stage of CTCL is more likely to have CD7 deletion in peripheral blood.