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Transfer at the blastocyst stage has been reported to improve success rates in recent years. The objective of this article was to study the clinical outcome of blastocyst transfer and its influencing factors in freeze-thaw cycles. 319 patients were undergoing blastocyst culture after thawing of D3 cleavage stage embryo from 2006 to 2007. 11 patients had no blastocyst available for transfer. Blastocysts transferred on day 5 implanted more than two times the rate of those transferred on day 6 (41.51% vs. 19.92%) . Delivery rates were twice as high among the 176 day 5 patients compared to the 132 day 6 transfer patients (52.72% vs. 23.48%) . The implantation and delivery rates were decreased among with the more previous transfer times. The implantation and delivery rates were 22.95% and 27.12% in patients >3 previous transfer times. For good prognosis patients, we compared the clinique outcome between D3 transfer and blastocyst transfer group. There are no differences in pregnancy and delivery rates between the two groups, but the implantation rate was higher in blastocyst transfer group than in D3 group and miscarriage rate in blastocyst transfer group was significantly decreased. Introducing blastocyst culture and transfer to good prognosis patients in frozen-thawed cycle become an important method to decrease the multiple pregnancy.