【摘 要】
：
In pharmacologic doses, niacin (nicotinic acid), remains an agent whose broad-spectrum beneficial effects on cardiovascular disease are unsurpassed.It lowers atherogenic apo B lipoproteins (eg LDL, VL
【机 构】
：
Atherosclerosis Research Center Long Beach VA Medical Center USA
【出 处】
：
BITs 2rd Annual World Cancer Congress of Cardiology-2010(201
论文部分内容阅读
In pharmacologic doses, niacin (nicotinic acid), remains an agent whose broad-spectrum beneficial effects on cardiovascular disease are unsurpassed.It lowers atherogenic apo B lipoproteins (eg LDL, VLDL) and raises anti atherogenic apo A-I lipoproteins (HDL).Its non-lipid reported effects include raising adiponectin, prostaglandins,and lowering oxidative stress.In clinical trials, used alone, it reduced risk for cardiovascular events comparable to statins.In arteriographic studies, it uniquely regresses atherosclerosis in coronary, femoral and carotid arteries when used with bile sequestrants or statins.
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