新细胞因子FAM19A4作为FPR1的配体调节巨噬细胞的功能

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：ytfonrt

【摘要】

：

研究背景:为了发现新的潜在细胞因子编码基因,我们与国家人类基因组北方研究中心合作,采用免疫基因组学策略,开展了人类潜在新细胞因子编码基因的生物信息学分析和功能研究.目前,我们共遴选得到了212个候选基因,构建了其中121个基因的真核细胞表达载体,验证了36个分泌蛋白,功能筛选平台鉴定其中4个对免疫细胞具有调控作用.

【作者】

：

李婷王晓林原婉琼张荷钰程迎迎张颖妹石爽马大龙韩文玲

【机构】

：

北京大学基础医学院免疫学系,卫生部医学免疫学重点实验室,北京大学人类疾病基因研究中心

【出处】

：

中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

【关键词】

：

FAM19A4 细胞因子巨噬细胞趋化吞噬

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

The therapeutic effects of BMSCs on silicosis via paracrine mechanisms in rats

The present study was designed to investigate the protective potential of BMSCs on silica-induced pulmonary injury in rats, and determine the underlying paracrine mechanisms.Following the successful e

会议

Functionization of REDVpeptide is benefit to complete re-endothelization of decellularized venous co

The tissue engineered venous valve has been considered as a promising alternative to treat deep venous insufficiency.We previously found that recellularization of decellularized venous conduit bearing

会议

Combined treatment with triiodothyronine and neural stem cells enhances neuroprotective effect on ch

Previous studies indicated the beneficial effects of Triiodothyronine (T3) and neural stem cells (NSCs) on chronic experimental autoimmune encephalomyelitis (EAE),a model of multiple sclerosis.Here, w

会议

Basic fibroblast growth factor protects bone marrow mesenchymal stem cells from hydrogen peroxide-in

Basic fibroblast growth factor (bFGF), a potent mitogen,inhibites apoptosis in many cell types, such as myocardial cells and NIH 3T3 cells.However, the direct effects of bFGF on bone marrow mesenchyma

会议

Exploring the multipotential differentiation of cardiac telocytes and their effects on myocardial re

Telocytes are a new class of interstitial cells present in heart.They are dispersed in the connective interstitium, setting up a three-dimensional myocardial architecture and, possibly,involved in cel

会议

溃肠宁多靶点治疗溃疡性结肠炎的临床研究

目的：观察溃肠宁治疗溃疡性结肠炎的临床疗效.方法：将64例患者按就诊顺序分为治疗组34例、对照组30例，治疗组予溃肠宁口服并灌肠；对照组口服柳氮磺吡啶肠溶片.疗程均10周.结果：在诱导缓解率、证候改善有效率、症状体征改善、安全性、远期疗效方面，治疗组优于对照组(P＜0.05).结论：溃肠宁多靶点治疗溃疡性结肠炎脾胃虚弱夹湿热、肝郁、血瘀证型的效果较单纯西药治疗佳，值得进一步研究及临床推广.

会议

潘洋教授运用中医中药治疗溃疡性结肠炎的经验举隅

溃疡性结肠炎为现代难治性疾病之一，属中医"痢疾"、"泄泻"和"腹痛"范畴，潘洋教授根据多年临床经验运用中医辨证论治理论，认为本病辨证应以虚实为纲，实证以湿热下注为主，虚证以脾肾阳虚为主，确立清热化湿，益气健脾，温阳补肾，止血生肌为治则，采用中药内服配合中药灌肠的方法治疗溃疡性结肠炎，经大量临床观察疗效显著、具有毒副作用小、复发率低的优势。

会议

ATF3-mediated NRF2/HO1 signaling regulates TLR4 innate immune responses in mouse liver ischemia/repe

Background & Aims: Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that has been shown to repress inflammatory gene expression in multiple cell types and diseases.How

会议

基于TCR信号转导通路探讨LY294002对CD3mAb活化的T细胞及Mtb-Ag启动的gdT细胞调控作用

目的:观察磷脂酰肌醇3激酶(PI3K)特异性抑制剂LY294002对CD3mAb活化的T细胞及Mtb-Ag激活γδT细胞的影响,探讨PI3K在CD3mAb活化的T细胞及Mtb-Ag启动的γδT细胞TCR途径信号转导中作用.方法:分离获取健康人外周血单个核细胞(PBMC),用CD3mAb(CD3单克隆抗体)、PMA+IM(佛波醇酯+离子霉素)、Mtb-Ag(结核杆菌低分子多肽抗原)刺激PBMC,采用

会议

γδT细胞CD69分子信号转导LY294002CD3mAbPMA+IMMtb-Ag

Mannan-binding lectin Suppresses Peptidoglycan-induced Inflammatory Responses through the TLR2 Recep

Background: Peptidoglycan (PGN), the major cell wall component of Gram-positive bacteria, is known to elicit excessive proinflammatory cytokine production from immune cells.Mannan-binding lectin (MBL)

会议

Mannan-binding lectinpeptidoglycanToll-like receptor 2InflammationImmune reg

新细胞因子FAM19A4作为FPR1的配体调节巨噬细胞的功能

与本文相关的学术论文