【摘 要】
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Introduction and Purpose:Porcine reproductive and respiratory syndrome virus (PRRSV) causes the most important infectious disease which was a worldwide and serious threat to pig production.Based on se
【机 构】
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Military Veterinary Institute, Academy of Military Medical Science, Changchun 130122, China
【出 处】
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2013国际猪繁殖与呼吸综合征学术研讨会
论文部分内容阅读
Introduction and Purpose:Porcine reproductive and respiratory syndrome virus (PRRSV) causes the most important infectious disease which was a worldwide and serious threat to pig production.Based on serological characteristics,there are two main serotypes of PRRSV,named the European isolate (EU,type 1) and the Northern American isolate (NA,type 2),which share nucleotide homology of 54％ ～ 67％.The European type of PRRSV was restricted to Europe,while the American type of PRRSV was restricted to North America and Asia.However,the epidemic of PRRSV has break the regional restrictions,the European type of PRRSV have been reported in Asia and North America,and American wild-type PRRSV has been isolated in Europe recently.A PRRSV strain coexisting with NA and EU genotype could cause potential problems to PRRSV diagnostics and managements.In recent years,several the European type PRRSV field isolates were reported in several Asia countries such as South Korea,Thailand etc,and the European type PRRSV was also reported in China.The emergence of European type PRRSV in China brought great challenge to the prevention and control of PRRSV.In this study,DNA vaccine pVAX-EU-ORF3-ORF5,pVAX-EU-ORF3 and pVAX-EU-ORF5 were constructed basis on the European LV strain (M96262),analysis of its expression at the cellular level and comparison of its immunogenicitv bv animal experiment.
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