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Gastroparesis is frequent in diabetic patients.It is a well-recognized complication of long-standing diabetes.The symptom complex typically associated with gastroparesis occurs in 25%-55%of patients with long-standing type 1 or type 2 diabetes.However,the pathogenesis is not clear yet.The present study,the possibility as to whether the PDE3-dependent cGMP signal pathway is involved in diabetic gastropathy or gastroparesis was investigated in STZ-induced rats.