p62在tamoxifen诱导子宫内膜癌变中的作用和机制

来源 :浙江省免疫学会第十次学术大会 | 被引量 : 0次 | 上传用户：w8521843d

【摘要】

：

目的：乳腺癌是威胁妇女健康的主要恶性肿瘤,内分泌治疗是乳腺癌综合治疗的主要手段之一。他莫昔芬(Tamoxifen,TAM)一直是绝经前妇女乳腺癌辅助内分泌治疗的首选药物,但在其长期治疗过程中可能引起子宫内膜细胞的增殖及肥大,促进子宫内膜不典型增生、息肉甚至浸润性癌的形成,这在一定程度上影响了患者长期受益。但目前对TAM如何导致子宫内膜癌变的具体机制尚未完全阐明,我们将在此探讨p62在其中的可能作用

【作者】

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冯利锋杨利贤王娴金洪传

【机构】

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浙江大学医学院附属邵逸夫医院

【出处】

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浙江省免疫学会第十次学术大会

【发表日期】

：

2016年8期

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p62在tamoxifen诱导子宫内膜癌变中的作用和机制

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