The structural basis of RKIP binding with its substrate Raf-11-147

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户:luzhiqing
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Raft kinase inhibitor protein (RKIP) directly interacts with Rafl kinase, thereby regulatingthe Rafl/MEK/ERK pathway which is vital for cell growth and differentiation.However, little is known about the molecular mechanism of RKIP binding with Rafl.
其他文献
As a well-known phenomenon,total mRNAs poorly correlate to proteins in their abundances as reported.Recent findings calculated with bivariate models suggested even poorer such correlation,while focusi
细胞内,大分子化合物的核质穿梭是一个信号依赖的主动运输过程,分为经典入核途径与非经典入核途径两种,主要由核质转运受体家族负责介导.同源异型蛋白Nkx2-2是胚胎脑与胰腺正常发育过程中必需的转录调节因子.
Somatic mutation and altered protein expression patterns cause inappropriate activation and deactivation of key players in cellular signaling,resulting in oncogenic phenotypes.
Rotenone,an inhibitor of the mitochondrial electron transport chain complex,may induce neuronal apoptosis contributing to neurodegenerative diseases.
The bitter tastant chloroquine activates bitter taste receptors (TAS2Rs) and signaling through G protein subtype Gβγ to increase intracellular Ca2+ in airway muscle cells,and this Ca2+ increase result
膀胱癌是我国泌尿生殖系统最常见的肿瘤,其发病率和死亡率均居泌尿肿瘤首位.膀胱癌的演进是多阶段多基因参与的结果,其中DNA损伤应答过程的异常可通过影响细胞周期、凋亡和DNA修复等重要生命活动导致肿瘤基因组的高度不稳定,与肿瘤的发生、发展密切相关.
慢性粒细胞白血病(CML)是正常造血干细胞获得性形成BCR-ABL融合基因而诱发的克隆性血液肿瘤.抑制BCR-ABL酪氨酸激酶的小分子化合物,如Imatinib mesylate能使慢性期患者得到有效缓解,但单一药物尚不能治愈该疾病;这表明深入研究CML致病分子机制、寻找新的治疗靶标仍是CML研究的重点.
Taurine,a conditional essential amino acid,plays a critical role in cardiovascular functions.Here we examined the effects of taurine on mitochondria and Endoplasmic Reticulum in rat cardiomyocytes dur
Huntingtons disease (HD) is a progressive neurodegenerative disorder caused by thepolyglutamine (polyQ) expansion in huntingtin (Htt) protein, a ubiquitously expressed proteinof yet unknown function.G
To analyze the backbone dynamics of AK1, we performed 15N relaxation measurementsusing NMR spectroscopy.Totally,115 assigned residues were used except the residueswith overlapping signals that were no
会议