【摘 要】
：
聚腺苷酸专一性核糖核酸酶(poly(A)-specific ribonuclease,PARN,EC 3.1.13.4)是真核细胞中特异性催化mRNA 3端poly(A)尾巴降解的酶,在调控mRNA的加工、翻译效率和降解等
【机 构】
：
清华大学生命科学学院,生物膜与膜生物工程国家重点实验室,北京100084
【出 处】
：
第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会
论文部分内容阅读
聚腺苷酸专一性核糖核酸酶(poly(A)-specific ribonuclease,PARN,EC 3.1.13.4)是真核细胞中特异性催化mRNA 3端poly(A)尾巴降解的酶,在调控mRNA的加工、翻译效率和降解等过程中发挥重要作用.PARN参与了多种重要生理过程,如卵母细胞成熟、细胞周期调控、对多种胁迫刺激的应答等,并且在一些癌症如白血病中表达量显著上调,可能作为潜在的癌症诊断marker和药物作用靶点.PARN是一个多结构域的同源二聚体,含核酸酶结构域、R3H结构域、RRM结构域和C端结构域(CTD).
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