论文部分内容阅读
Background and purpose: Sphingolipid de novo biosynthesis is related to nonalcoholic fatty liver disease or hepatic steatosis.However, the mechanism is still unclear.Sphingomyelin synthase (SMS), using ceramide as one of the substrates to produce sphingomyelin, sits at the crossroads of sphingolipid biosynthesis.SMS has 2 isoforms: SMS1 and SMS2.SMS2 is the major isoform in liver.Experimental approach and results: To investigate the relationship between liver SMS2 activity-mediated sphingolipid changes and hepatic steatosis, we used 2 mouse models: Sms2 liver-specific transgenic and Sms2 knockout mice.We found that Sms2 liver-specific transgenic livers have lower ceramide and higher sphingomyelin, whereas Sms2 knockout livers have higher ceramide and lower sphingomyelin.