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Objective: To summary our experiences of stereotactic biopsy for the diagnosis of the intracranial lesion in patients with AIDS.Methods: 7 AIDS patients with intracranial lesion underwent stereotactic biopsy were analyzed retrospectively from November 2010 to January 2016.There were 4 males and 3 females,15 to 49 years (mean 36 years) old.The disease history ranges from 1month to 1 year.