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目的观察2型糖尿病患者血清3-硝基酪氨酸水平及其相关因素分析。方法按随机病例对照研究方法,抽取确诊的2型糖尿病患者109例(病例组),非糖尿病患者57例(对照组)。对研究对象进行人体测量、血生化指标检测和血清3-硝基酪氨酸(3-NT)水平测定,并分析3-NT的相关因素。结果两组入选受试者的年龄、体重等指标均无显著性差异;病例组血糖、糖化血清蛋白、总胆固醇、载脂蛋白C2(ApoC2)明显高于对照组(P<0.05)。病例组3-NT水平明显高于对照组,且病例组男性高于对照组男性、病例组女性高于对照组女性(P<0.05);BMI≥28糖尿病患者3-NT明显高于BMI<24糖尿病患者;空腹血糖>6.1mmol/L糖尿病患者3-NT水平也高于空腹血糖≤6.1mmol/L糖尿病患者(P<0.05);病例组回归分析显示与3-NT线性相关性最大的因素依次为糖化血红蛋白、糖化血清蛋白、低密度脂蛋白胆固醇(LDL-c)。结论糖尿病患者3-NT水平明显高于对照人群;3-NT水平与糖化血红蛋白、糖化血清蛋白、LDL-c等因素密切相关。
Objective To observe the serum levels of 3-nitrotyrosine and its related factors in type 2 diabetic patients. Methods According to the randomized case-control study method, 109 confirmed type 2 diabetic patients (case group) and 57 non-diabetic patients (control group) were collected. The subjects were measured by human body, blood biochemical indicators and serum 3-nitrotyrosine (3-NT) levels were measured, and 3-NT related factors were analyzed. Results There was no significant difference in the age, body weight and other indexes between the two groups. The blood glucose, glycosylated serum protein, total cholesterol and apolipoprotein C2 (ApoC2) were significantly higher in the two groups than those in the control group (P <0.05). The 3-NT level in case group was significantly higher than that in control group, and the male in case group was higher than that in control group (P <0.05). The 3-NT level in BMI≥28 diabetic group was significantly higher than that in control group The level of 3-NT in diabetics with fasting blood glucose> 6.1 mmol / L was also higher than that in patients with fasting glucose ≤6.1 mmol / L (P <0.05). The regression analysis showed that the factors with the most linear relationship with 3-NT Glycated hemoglobin, glycated serum protein, low-density lipoprotein cholesterol (LDL-c). Conclusions The level of 3-NT in diabetic patients is significantly higher than that in control subjects. The level of 3-NT is closely related to such factors as glycosylated hemoglobin, glycosylated serum protein and LDL-c.