FISH+CD34+CD38-cells detected in newly diagnosed acute myeloid leukemia patients can predict the cli

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Background In acute myeloid leukemia (AML),the leukemia initiating cells (LICs) or leukemia stem cells (LSCs) is found within the CD34+CD38- cell compartment.The LICs subpopulation survives chemotherapy and is most probable the cause of minimal residual disease (MRD),which in turn is thought to cause relapse.The aim of this study was to determine the prognostic value of the percentage of LICs in blasts at diagnosis.
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