Chemotherapeutic and radiation treatments cause a variety of genotoxic insults that lead to cell death in rapidly proliferating cancer cells.To survive genotoxic insults,cancer cells depend on multiple DNA repair pathways.The selected choice of a potential chemotherapeutic agent acting on the impaired DNA repair pathway in a certain tumor would result in more personalized treatment to kill tumors.We recently reported that human putative tumor suppressor protein, ATAD5 is stabilized in response to almost all genotoxic insults.