2,4,6-trinitrotoluene(TNT)and its byproducts Drinitrotoluene(DNT)pose a significant risk to human health and other living organisms.Nowadays,the existing qu
Organophosphatecompounds(OPs)are most toxic insecticides used today,adversely affecting the human nervous system even at low levels of exposure.They have lo
P21-activated kinase 4(PAK4),a serine/threonine protein kinase,was originally identified as an effector protein for Rho-family GTPases.1 PAK4 plays an impor
Two-layer ONIOM calculations combined quantum mechanics(QM)and molecular mechanics(MM)were performed to explore the binding modes of five novel cis-platinum
Microtubules are an attractive molecular target for anticancer agents.Combretastatin A-4(CA-4)is strong tubulin polymerization inhibitors binding to the col