【摘 要】
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Tolerance induction or re-establishment of the immunological homeostasis after transplantation is the basis of a successful transplantation.Non-autograft organ disrupts this maintenance drastically, a
【机 构】
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University of Groningen The Netherlands
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Tolerance induction or re-establishment of the immunological homeostasis after transplantation is the basis of a successful transplantation.Non-autograft organ disrupts this maintenance drastically, as the normal tendency of the immune system is rejection of foreign invaders.To overcome this unwilling response, current method involves cross-matching of the blood group and genotype of the donor and recipient followed by post-surgery general immunosuppression for a pseudo-tolerance induction.Therefore, the specific unresponsiveness of the recipient immune system to the donor organ, implied by tolerance, is not achieved in this process.Whether genotype matching is the main parameter in tolerance induction, while we see pregnancy and autoimmunity?
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