Objective: To detect the inhibitory effects of CAL-101, a selective inhibitor of PI3Kδ, on Burkitt lymphoma cell line Raji and diffused large B-cell lymphoma cell line SUDHL-10 and its relative mechanism.Methods: Raji and SUDHL-10 cells were treated with varying concentrations of CAL-101.MTT assay was performed to determine the inhibitory effects of CAL-101 on lymphoma cells.Cell apoptosis was measured by Annexin Ⅴ/PI and DAPI staining.Migration assays were performed with transwell to detect the migration of lymphoma cells derived by stromal cell line HK.Western blot was used to detect phosphorylation of the ERK pathway.MTT and CalcuSyn software analyses were performed to detect whether the combination of CAL-101 with bortezomib resulted in a synergistic cytotoxic effect.