【摘 要】
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Hypertension is a major risk factor in cardiovascular disease,a leading cause of death in Canada and many countries worldwide.Angiotensin-Ⅰ-converting enzy
【机 构】
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Food,Nutrition&Health(FNH)UniversityofBritishColumbiaCanada
【出 处】
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2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
Hypertension is a major risk factor in cardiovascular disease,a leading cause of death in Canada and many countries worldwide.Angiotensin-Ⅰ-converting enzyme (ACE,EC 3.4.15.1),also known as peptidyl dipeptidase A,is a key enzyme in the renin-angiotensin system which regulates blood pressure and electrolyte homeostasis.The synthetic ACE inhibitor drugs prescribed to manage hypertension may effectively lower blood pressure,but are frequently accompanied by undesirable side effects.In contrast,ACE-inhibitory peptides derived from food proteins and fermented foods have demonstrated efficacy without side effects for patients with borderline or mild hypertension,while showing no effect on normotensive individuals.
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