【摘 要】
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OBJECTIVE To examine whether PEBP partici pates in opioid dependence through modulating activation of MAPK pathway.METHODS AND RESULTS In CHO cell stably expressing μ receptor (MOR-CHO) or SH-SY5Y cel
【出 处】
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第十四届中国神经精神药理学学术会议
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OBJECTIVE To examine whether PEBP partici pates in opioid dependence through modulating activation of MAPK pathway.METHODS AND RESULTS In CHO cell stably expressing μ receptor (MOR-CHO) or SH-SY5Y cell expressing endogenous μ receptor, morphine stimulated phos phorylation of ERK but not PEBP in time-and dose-dependent manner.No significant change of pPEBP or PEBP was detected after a 48h chronic treatment of morphine in MOR-CHO or SH-SY5Y cell.
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