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Azinomycin B.was isolated from Streptomyces sahachiroi,is a complex natural product containing densely assembled functionalities with potent antitumor activity.Cloning and sequence analysis of the azi gene cluster revealed an iterafive type 1 polyketide synthase (PKS) gene,five nonribosomal peptide synthetases (NRPSs) genes and numerous genes encoding the biosynthesis of unusual building blocks and tailoring steps for azinomycin B production.