Recent evidence suggests that endothelial cells from neighboring preexisting capillaries are not the only source of increased tumor vascularization.Bone marrow erived endothelial progenitor cells (EPC) are also thought to contribute to the formation of new vessels in tumors, a process known as vasculogenesis.Firstly it was testified in our group that mobilized EPCs participate in tumor vasculogenesis of HCC, AC 133 gene or antigen in peripheral blood and liver tissue could be used as a biomarker for predicting the progression of HCC.