Design,Synthesis and Biological Evaluation of Nitric oxide/Hydrogen Sulfide-Donating Hybrids of 3-n-

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户:zhongkelong
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
其他文献
一氧化氮(NO)作为信使物质或效应分子在心血管、免疫等系统发挥重要的生理作用[1]。由于NO 的多种生物活性以及"双刃剑"的作用,利用高浓度的NO来实现抗肿瘤则需要选择性和靶向性地将NO定点输送到肿瘤细胞中,尽可能的减少NO 在非靶部位的释放而带来的副作用。
2005年,拥有自主知识产权的丁苯酞软胶囊被国家药监局批准上市,成为国际上首个作用于急性缺血性脑卒中多个病理环节的创新药物。丁苯酞能重建脑缺血区微循环,显著缩小脑梗塞面积,并能保护线粒体功能,改善脑代谢。
Directly disrupting the Keap1-Nrf2 protein-protein interaction(PPI)has been proven an effective way to activate Nrf2.On the basis of the potent Keap1-Nrf2 PPI inhibitor reported by our group previousl
Rosiglitazone is clinically used to treat insulin resistance.However,its long-term administration will increase the incidence of cardiovascular side effects.[1] Given the beneficial effects of nitric
会议
α,β-不饱和酮化合物CDDO-Me具有显著的抗炎和抗肿瘤活性[1],但在进行2型糖尿病慢性肾病Ⅲ期临床研究时,发现它有严重的心血管不良反应[2]。我们推测,CDDO-MeA环上的α-氰基烯酮反应性极强,除与靶标作用外,也可能与非靶标蛋白的巯基发生了迈克尔加成,产生了副作用。
The epidermal growth factor receptor(EGFR)is one important member of protein tyrosine kinases.Aberrant activation of EGFR has been linked to tumor proliferation,invasion and metastasis.1,2 Several rev
The synthesis of 4-isochromanones via Parham-type cyclization with Weinreb amide as the internal electrophilic group,t-BuLi as the lithium reagent was described.The reaction was very efficient and cou
酸性神经鞘磷脂酶(ASM)水解鞘磷脂生成神经酰胺和磷酰胆碱,调节体内神经鞘磷脂的动态平衡及神经酰胺参与的信号转导,在动脉粥样硬化,抑郁症,肺泡组织损伤,肝损伤等多种疾病的发生发展过程中起着重要的作用[1]。
Heat shock protein 90(Hsp90)is highly expressed in many tumor cells and is associated with the maintenance of malignant phenotypes.Targeting Hsp90 has shown some therapeutic success in solid and hemat
会议