Objective:Death caused by cardiovascular diseases and cerebrovascular diseases whose major pathological alteration is atherosclerosis(AS)accounted for more than 25﹪ of all death of human kinds,which is parallel to that caused by malignant tumors.However,the prevalence rate of AS is much higher that of malignant tumors and a large number of patients with AS cannot take care of themselves because of disability or administration in a long period,thus bringing a heavy burden to both economics and society,and becoming a serious public health problem.Conclusions:1.Injection of oxLDL in neonatal rats can induce T-cell immunologic tolerance without affecting the activity of T cells,and inhabites the humoral immunization to oxLDL.2.Although we cannot make sure injection of VLDL in neonatal rats can induce immunologic tolerance,we found it may increase the lovels of T-cell immune response.3.Injection of oxLDL and VLDL in neonatal rats can inhabited the humoral immunization to oxLDL and VLDL.4.Neonatal rats were injected with oxLDL to prevent the injury of artery endothelial cells to some extent.5.It cannot still be concluded that experimental measure had significant effects on blood lipid levels.6.oxLDL is better than VLDL to prevent AS.