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目的研究老年慢性阻塞性肺疾病(COPD)患者在急性加重期血浆D-二聚体(D-D)、凝血酶抗凝血酶复合物(TAT)、纤溶酶抗纤溶酶复合物(PAP)的含量及临床意义。方法整理濮阳市人民医院收治的25例COPD急性加重期患者的临床资料,同时收集20例急性缓解期患者的临床资料,对患者分别进行静脉血测定,对各项指标进行对比分析。结果 COPD急性加重期患者的D-D、TAT、PAP等指标明显高于缓解期患者,血凝度较高,血栓形成情况较多。结论老年COPD患者急性加重期的血浆D-D、TAT及PAP含量明显增高,容易形成血栓,出现弥散性血管内凝血,导致患者死亡,联合检测D-D、TAT及PAP可有效地掌握患者的临床情况及治疗效果,为临床治疗提供一定的参考。
Objective To investigate the relationship between plasma D-dimer (DD), thrombin antithrombin complex (TAT) and plasmin anti-plasmin complex (PAP) in elderly patients with chronic obstructive pulmonary disease (COPD) Content and clinical significance. Methods The clinical data of 25 patients with acute exacerbation of COPD admitted in Puyang Municipal People’s Hospital were collected, and the clinical data of 20 patients with acute remission were collected. The venous blood was measured and the indicators were compared. Results The indexes of D-D, TAT, PAP and so on in patients with acute exacerbation of COPD were significantly higher than those in patients of remission, with high blood coagulation and more thrombosis. Conclusion The plasma levels of DD, TAT and PAP in elderly patients with acute exacerbation of COPD are significantly higher than those in patients with chronic obstructive pulmonary disease (COPD). Thrombus is easily thrombosed and disseminated intravascular coagulation occurs, leading to the death of patients. Combined detection of DD, TAT and PAP can effectively understand the clinical situation and treatment of patients Effect, provide some reference for clinical treatment.