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目的探讨双歧杆菌活菌制剂联合柳氮磺吡啶灌肠治疗溃疡性结肠炎(UC)的临床疗效。方法选取通州区人民医院2013年1月—2016年4月收治的UC患者49例,随机分为对照组(n=24)和治疗组(n=25)。对照组患者采用柳氮磺吡啶灌肠治疗,治疗组患者在对照组的基础上给予双歧杆菌四联活菌片治疗,两组患者均持续治疗1个疗程。比较两组患者腹痛消失时间、黏液脓血便消失时间及腹泻消失时间、临床疗效,观察患者治疗后3、6个月疾病复发情况。结果治疗组患者腹痛消失时间、黏液脓血便消失时间及腹泻消失时间短于对照组(P<0.05)。治疗组患者治疗总有效率高于对照组(P<0.05)。治疗组患者治疗后3个月、6个月复发率低于对照组(P<0.05)。结论采用双歧杆菌活菌制剂联合柳氮磺吡啶灌肠治疗UC的临床疗效确切,可有效改善患者的临床症状,且复发率低。
Objective To investigate the clinical efficacy of live bifidobacterium preparation combined with sulfasalazine enema in the treatment of ulcerative colitis (UC). Methods Forty-nine UC patients admitted from January 2013 to April 2016 in Tongzhou District People’s Hospital were randomly divided into control group (n = 24) and treatment group (n = 25). Patients in the control group were treated with sulfasalazine enema. Patients in the treatment group were treated with live bifidobacterium viable Bifidobacterium tablets on the basis of the control group. Both groups were treated for one course of treatment. The disappearance time of abdominal pain, the disappearance of mucus and pus and blood and the disappearance of diarrhea and clinical efficacy were compared between two groups. The recurrence of the disease was observed 3 and 6 months after treatment. Results The disappearance time of abdominal pain, the disappearance of mucus and pus and blood and disappearance of diarrhea in treatment group were shorter than those in control group (P <0.05). The total effective rate of treatment group was higher than that of control group (P <0.05). Patients in the treatment group had a lower recurrence rate at 3 months and 6 months after treatment than those in the control group (P <0.05). Conclusion The clinical efficacy of viable bifidobacterium combined with sulfasalazine enema in the treatment of UC is accurate and can effectively improve the clinical symptoms of patients with low recurrence rate.