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目的通过对妊娠妇女阴道分泌物进行分离培养及药敏试验,了解妊娠妇女念珠菌的感染情况及其对常用抗真菌药物的敏感性。方法用科玛嘉念珠菌显色培养基对阴道分泌物进行培养,ATB半自动微生物培养鉴定仪对分离的菌株进行鉴定和药敏分析。结果分离念珠菌256例,主要是白色念珠菌。所有分离的念珠菌对两性霉素B和5-氟胞嘧啶敏感,对伊曲康唑、伏立康唑、氟康唑有一定程度的耐药。结论妊娠妇女阴道念珠菌感染以白色念珠菌为主,对于唑类抗生素的耐药性呈现一定程度的上升趋势,应加强念珠菌的检测和药物敏感分析。
Objective To isolate and culture vaginal secretions of pregnant women and drug susceptibility testing to understand the prevalence of Candida in pregnant women and its sensitivity to common antifungal drugs. Methods The vaginal secretions were cultured with Candida kamabacter colorimetric medium and the strains were identified by ATB semi-automatic microbial culture and drug susceptibility analysis. Results Candida 256 cases were isolated, mainly Candida albicans. All isolates of Candida were sensitive to amphotericin B and 5-fluorocytosine and had some resistance to itraconazole, voriconazole and fluconazole. Conclusion Candida albicans infection in pregnant women is mainly Candida albicans, and the resistance to azole antibiotics shows a certain degree of upward trend. Candidiasis should be strengthened and drug sensitivity analysis should be strengthened.