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[目的]探讨慢性乙型病毒性肝炎(CHB)患者肝组织学改变的相关影响因素。[方法]选取CHB患者55例,根据肝炎病情程度分为G1S0-1组与G2-4S2-4组,分析2组患者性别、年龄、血清丙氨酸转氨酶(ALT)、乙肝血清标志物(HBeAg)及乙肝病毒DNA(HBV DNA)水平与肝脏组织学改变的关系。[结果]肝脏的炎症活动度和纤维化程度随年龄的增大、血清ALT及HBV DNA水平的增高而加重,多因素分析显示HBV DNA水平是慢性乙肝患者肝组织学改变的独立影响因素。[结论]慢性乙肝患者肝组织病变程度与患者年龄、血清ALT及HBV DNA水平有相关性,其中HBV DNA水平是慢性乙型肝炎患者肝组织病变的独立影响因素。
[Objective] To investigate the related factors of liver histology in patients with chronic hepatitis B (CHB). [Methods] Fifty-five CHB patients were divided into G1S0-1 group and G2-4S2-4 group according to the severity of hepatitis. The gender, age, serum ALT, HBeAg ) And hepatitis B virus DNA (HBV DNA) levels and liver histological changes. [Result] The degree of inflammatory activity and fibrosis in liver increased with age, serum ALT and HBV DNA levels increased, and multivariate analysis showed that HBV DNA level was an independent factor affecting the changes of liver histology in chronic hepatitis B patients. [Conclusion] The degree of liver lesions in patients with chronic hepatitis B is related to patient ’s age, serum ALT and HBV DNA levels. HBV DNA level is an independent factor affecting the liver lesions in patients with chronic hepatitis B.