论文部分内容阅读
制备并用UV、循环伏安（CV）和NMR法研究了NAMI（新抗肿瘤转移抑制剂，trans-[RuCl4（DMSO）（imidazole）]Na·2DMSO）衍生物trans-[RuCl4（DMSO）（2-Melm）]Na·2DMSO（2-MeIm=2-甲基咪唑，化合物1）和trans-[RuCl4（DMSO）-（N-Etlm）]Na·2DMSO（N-Etlm=N-乙基咪唑，化合物21的水解机理一动力学、溶液稳定性和电化学性质．化合物1和化合物2与NAMI相似，在pH 7．40的缓冲溶液中发生两步脱氯水解反应（Ⅰ氯水解及Ⅱ氯水解）（分步反应）；在酸性溶液（pH5．00）中脱DMSO水解．通过线性拟合得到各水解反应速率常数Kobs及半衰期t1／2．结果表明化合物在酸性溶液中的稳定性相对较高．在NAMI衍生物咪唑环的N位引入乙基比在2位引入甲基生成的化合物稳定．含氮配体相同时，NAMI-A（新抗肿瘤转移抑制剂，A：该系列中的第一个化合物，trans-[RuCl4（DMSO）（imidazole）][Himidazole]）衍生物略比相应的NAMI衍生物稳定．“,”Two NAMI （new antitumor metastasis inhibitor; trans-[RuC14（DMSO）（imidazole）]Nao2DMSO） derivatives, trans-[RuC14（DMSO）（2-MeIm）Na,2DMSO （2-MeIm=2-methyl imidazole, Compd. l） and trans-[RuC14（DMSO）（N-EtIm）]Na.2DMSO （N-EtIm=N-ethyl imidazole, Compd. 2） were prepared. Their hydrolytic mechanism-kinetics in pH 7.40/5.00 buffer solution and stability in physiological condition were investigated by UV, cyclic voltammetry （CV） and NMR. Similar to NAMI, both compounds undergo two well separated steps chloro-hydrolysis in pH 7.40 buffer solution; while dimethyl sulfoxide （DMSO） hydrolyze in pH 5.00 acetic buffer solution. The kobs and t1/2 for each reaction were determined. In conclusion, the stability of the complex in acidic solution is much more stable. The stability of the complex formed by introducing ethyl group at N position of imidazole ring would be much better than that of complex formed by introducing methyl group at 2 position of imidazole. The NAMI-A （new antitumuor metastasis inhibitor, A： this is the first of a series; trans-[RuCl4（DMSO）（imidazole）][Himidazole]） derivatives are somewhat morestable than the relative NAMI derivatives.