美国Johns Hopkins医院的Order教教,报道了他用放射物标记的抗铁蛋白单克隆抗体,治疗不能手术的肝癌和顽固性晚期何杰金氏病的经验。他指出选用这种放射免疫结合物,是因为它可作用于铁蛋白,而铁蛋白又大量聚集于癌细胞膜上。这样可使大剂量的放射作用在瘤细胞,而较少影响正常细胞。 The Order of the Johns Hopkins Hospital in the United States reported on his experience with radiolabeled anti-ferritin monoclonal antibodies for the treatment of inoperable liver cancer and refractory late-stage Hodgkin’s disease. He pointed out that this radioimmunoconjugate was chosen because it acts on ferritin, which in turn accumulates on the cancer cell membrane. This allows large doses of radiation to act on neoplastic cells and less to affect normal cells.