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本文采用实验性肺转移模型定量分析了环磷酰胺对肿瘤血源转移的影响及其作用机理。实验发现,(1)环磷酰胺预处理动物后以剂量依赖性方式促进肿瘤转移;(2)环磷酰胺预处理对血源瘤细胞在体内的分布无明显影响,但显著抑制器官中停驻瘤细胞的清除;(3)给环磷酰胺处理动物过继富含自然杀伤(NK)活性的脾细胞后可以恢复对血源瘤细胞的清除以及抑制肿瘤转移;(4)环磷酰胺预处理显著抑制小鼠体内NK活性。结果表明,环磷酰胺预处理小鼠可以抑制其体内NK活性,阻滞停驻于靶器官中瘤细胞的清除,从而促进肿瘤转移。
In this paper, experimental lung metastasis model quantitative analysis of cyclophosphamide on tumor blood transfer and its mechanism of action. The results showed that: (1) cyclophosphamide pretreatment of animals in a dose-dependent manner to promote tumor metastasis; (2) cyclophosphamide pretreatment on blood cells in the distribution of the body had no significant effect, but significantly inhibited the organ in the station (3) Cyclophosphamide-treated animals can resume the clearance of blood-derived tumor cells and inhibit tumor metastasis after adoptively immunizing spleen cells with natural killer (NK) activity; (4) Cyclophosphamide pretreatment is significant Inhibit NK activity in mice. The results showed that cyclophosphamide pretreatment mice can inhibit NK activity in vivo, blocking the removal of tumor cells parked in target organs, thereby promoting tumor metastasis.